|MultiBD Resource1 #685204|
MultiBD is an R package for direct likelihood-based inference of multivariate birth-death processes. 
Funding: This project is supported in part through the National Science Foundation grant DMS 1264153 and National Institutes of Health grant R01 AI107034.
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|Link Birth/birth-death processes and their computable transition probabilities with biological applications|
Author: Lam Si Tung Ho, Jason Xu, Forrest W. Crawford, Vladimir N. Minin, Marc A. Suchard
Publication date: 24 July 2017
Publication info: Journal of Mathematical Biology volume 76, pages911–944 (2018)
Cited by: David Price 1:50 PM 15 September 2022 GMT
|Excerpt / Summary|
Birth-death processes track the size of a univariate population, but many biological systems involve interaction between populations, necessitating models for two or more populations simultaneously. A lack of efficient methods for evaluating finite-time transition probabilities of bivariate processes, however, has restricted statistical inference in these models. Researchers rely on computationally expensive methods such as matrix exponentiation or Monte Carlo approximation, restricting likelihood-based inference to small systems, or indirect methods such as approximate Bayesian computation. In this paper, we introduce the birth/birth-death process, a tractable bivariate extension of the birth-death process, where rates are allowed to be nonlinear. We develop an efficient algorithm to calculate its transition probabilities using a continued fraction representation of their Laplace transforms. Next, we identify several exemplary models arising in molecular epidemiology, macro-parasite evolution, and infectious disease modeling that fall within this class, and demonstrate advantages of our proposed method over existing approaches to inference in these models. Notably, the ubiquitous stochastic susceptible-infectious-removed (SIR) model falls within this class, and we emphasize that computable transition probabilities newly enable direct inference of parameters in the SIR model. We also propose a very fast method for approximating the transition probabilities under the SIR model via a novel branching process simplification, and compare it to the continued fraction representation method with application to the 17th century plague in Eyam. Although the two methods produce similar maximum a posteriori estimates, the branching process approximation fails to capture the correlation structure in the joint posterior distribution.
|Link Direct likelihood-based inference for discretely observed stochastic compartmental models of infectious disease|
Author: Lam Si Tung Ho, Forrest W. Crawford, Marc A. Suchard
Publication date: 25 July 2018
Publication info: arXiv:1608.06769v2 [stat.CO]
Cited by: David Price 1:53 PM 15 September 2022 GMT
|Excerpt / Summary|
Stochastic compartmental models are important tools for understanding the course of infectious diseases epidemics in populations and in prospective evaluation of intervention policies. However, calculating the likelihood for discretely observed data from even simple models -- such as the ubiquitous susceptible-infectious-removed (SIR) model -- has been considered computationally intractable, since its formulation almost a century ago. Recently researchers have proposed methods to circumvent this limitation through data augmentation or approximation, but these approaches often suffer from high computational cost or loss of accuracy. We develop the mathematical foundation and an efficient algorithm to compute the likelihood for discretely observed data from a broad class of stochastic compartmental models. We also give expressions for the derivatives of the transition probabilities using the same technique, making possible inference via Hamiltonian Monte Carlo (HMC). We use the 17th century plague in Eyam, a classic example of the SIR model, to compare our recursion method to sequential Monte Carlo, analyze using HMC, and assess the model assumptions. We also apply our direct likelihood evaluation to perform Bayesian inference for the 2014-2015 Ebola outbreak in Guinea. The results suggest that the epidemic infectious rates have decreased since October 2014 in the Southeast region of Guinea, while rates remain the same in other regions, facilitating understanding of the outbreak and the effectiveness of Ebola control interventions.