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Streptococcus pneumoniae
Interest
1
#716661
Tags: Pneumococcus, Pneumococcal disease
CONTEXT
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EIDM »
EIDM
EIDM ☜The Emerging Infectious Diseases Modelling Initiative (EIDM) – by the Public Health Agency of Canada and NSERC – aims to establish multi-disciplinary network(s) of specialists across the country in modelling infectious diseases to be applied to public needs associated with emerging infectious diseases and pandemics such as COVID-19. [1]☜F1CEB7
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Research interests »
Research interests
Research interests☜☜9FDEF6
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Streptococcus pneumoniae
Streptococcus pneumoniae☜☜9FDEF6
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Caroline Colijn »
Caroline Colijn
Caroline Colijn☜Dr. Caroline Colijn works at the interface of mathematics, evolution, infection and public health, and leads the MAGPIE research group. She joined SFUs Mathematics Department in 2018 as a Canada 150 Research Chair in Mathematics for Infection, Evolution and Public Health. She has broad interests in applications of mathematics to questions in evolution and public health, and was a founding member of Imperial College Londons Centre for the Mathematics of Precision Healthcare.☜FFFACD
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Alexander Rutherford »
Alexander Rutherford
Alexander Rutherford☜Dr. Rutherford is the Director for the CSMG. Prior to joining the CSMG, he was the Scientific Executive Officer at the Pacific Institute for the Mathematical Sciences (PIMS). ☜FFFACD
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Pathogens »
Pathogens
Pathogens☜☜FFFACD
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Respiratory infections »
Respiratory infections
Respiratory infections☜☜FFFACD
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Vaccination »
Vaccination
Vaccination☜☜FFFACD
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[1]
Pneumococcal population dynamics: Investigating vaccine-induced changes through multiscale modelling
Author:
Nicola Mulberry, Alexander R. Rutherford, Caroline Colijn
Publication date:
28 December 2023
Publication info:
PLoS Comput Biol 19(12): e1011755
Cited by:
David Price
9:22 PM 10 January 2024 GMT
Citerank:
(3)
679748
Alexander Rutherford
Dr. Rutherford is the Director for the CSMG. Prior to joining the CSMG, he was the Scientific Executive Officer at the Pacific Institute for the Mathematical Sciences (PIMS).
10019
D3ABAB
,
679761
Caroline Colijn
Dr. Caroline Colijn works at the interface of mathematics, evolution, infection and public health, and leads the MAGPIE research group. She joined SFU's Mathematics Department in 2018 as a Canada 150 Research Chair in Mathematics for Infection, Evolution and Public Health. She has broad interests in applications of mathematics to questions in evolution and public health, and was a founding member of Imperial College London's Centre for the Mathematics of Precision Healthcare.
10019
D3ABAB
,
701020
CANMOD – Publications
Publications by CANMOD Members
144
B5ACA0
URL:
https://debategraph.org/handler.ashx?path=ROOT%2fu2928%2fjournal.pcbi.1011755.pdf&att=1
DOI:
https://doi.org/10.1371/journal.pcbi.1011755
Excerpt / Summary
[PLoS Computational Biology, 28 December 2023]
The mechanisms behind vaccine-induced strain replacement in the pneumococcus remain poorly understood. There is emerging evidence that distinct pneumococcal lineages can co-colonise for significant time periods, and that novel recombinants can readily emerge during natural colonisation. Despite this, patterns of post-vaccine replacement are indicative of competition between specific lineages. Here, we develop a multiscale transmission model to investigate explicitly how within host dynamics shape observed ecological patterns, both pre- and post-vaccination. Our model framework explores competition between and within strains defined by distinct antigenic, metabolic and resistance profiles. We allow for strains to freely co-colonise and recombine within hosts, and consider how each of these types may contribute to a strain’s overall fitness. Our results suggest that antigenic and resistance profiles are key drivers of post-vaccine success.
+About
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Entered by:-
David Price
NodeID:
#716661
Node type:
Interest
Entry date (GMT):
1/10/2024 9:22:00 PM
Last edit date (GMT):
1/10/2024 9:28:00 PM
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