Outstanding questions in 2002
Outstanding questions about influenza ecology and evolution, highlighted in Box 1 of the TREE review by Earn, Dushoff and Levin (2002).
In spite of considerable progress in understanding the cellular and molecular biology of flu viruses and recent advances in phylogenetics, some of the most basic ecological and evolutionary questions about the flu remain.
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Outstanding questions in 2002
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Implications for vaccination and antiviral drug strategies? »Implications for vaccination and antiviral drug strategies?
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Inter-hemispheric transmission vs over-summer carry-over? »Inter-hemispheric transmission vs over-summer carry-over?
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Reciprocal effects of intervention programmes? »Reciprocal effects of intervention programmes?
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Self-organization of strain structure & patterns of cross-reactivity? »Self-organization of strain structure & patterns of cross-reactivity?
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Timing and severity of pandemics? »Timing and severity of pandemics?
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What are the mechanisms of interaction between subtypes? »What are the mechanisms of interaction between subtypes?
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What makes the influenza so strongly seasonal? »What makes the influenza so strongly seasonal?
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Why do drifting subtypes persist and yet not diverge? »Why do drifting subtypes persist and yet not diverge?
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