Probiotics Interest1 #716063
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+Citaten (1)
- CitatenVoeg citaat toeList by: CiterankMapLink[1] The impact of respiratory infections and probiotic use on the nasal microbiota of frail residents in long-term care homes
Citerend uit: Dawn M.E. Bowdish, Laura Rossi, Mark Loeb, Jennie Johnstone, Louis P. Schenck, Michelle Fontes, Michael G. Surette, Fiona J. Whelan Publication date: 25 September 2023 Publication info: ERJ Open Research 2023 9: 00212-2023, Volume 9 Issue 5 Geciteerd door: David Price 12:38 PM 14 December 2023 GMT Citerank: (3) 679843Mark LoebProfessor at Pathology and Molecular Medicine (primary), Clinical Epidemiology and Biostatistics in the Department of Pathology and Molecular Medicine at McMaster University. Associate Member, Medicine and Michael G. DeGroote Chair in Infectious Diseases.10019D3ABAB, 701020CANMOD – PublicationsPublications by CANMOD Members144B5ACA0, 715284Respiratory infections859FDEF6 URL: DOI: https://doi.org/10.1183/23120541.00212-2023
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Fragment- [ERJ Open Research, 25 September 2023]
Background Residents in long-term care homes, who tend to be of advanced age and frail, are at increased risk of respiratory infections. The respiratory microbiota is known to change with age, but whether these changes contribute to the risk of infection is not known. Our goal was to determine how the nasal microbiota of frail older adults changes during symptoms of influenza-like illness (ILI) and how this may be impacted by enrolment in a placebo-controlled trial testing the feasibility of administering a Lactobacillus rhamnosus GG probiotic to prevent respiratory infection (2014–2017).
Methods The microbiome of the nasal (mid-turbinate) of 150 residents of long-term care homes was interrogated using 16S rRNA gene sequencing.
Results We identified a diverse and individualised microbiota which could be separated into nine distinct clusters based on Bray–Curtis distances. Samples collected during symptoms of ILI differed statistically from those collected pre- and post-cold and influenza season, and we observed decreased temporal stability (as measured by movement between clusters) in individuals who experienced ILI compared to those who did not.
Conclusions The use of probiotics decreased ILI-induced changes to the microbiota; however, it is not clear whether this decrease is sufficient to prevent respiratory illness. |