Evolution of the virus: variants, transmission bottlenecks and fitness
This project aims to develop models of virus evolution in-host, and extend our mathematical analysis to virus transmission bottlenecks, to determine probabilities of mutant virus transmission. We will quantify probabilities of virus evolution and transmission in-host and between hosts, given host heterogeneities in infection and immune system characteristics, and different characteristics of virus mutants that increase virus ‘fitness’.
  • Viral evolution can undermine the positive benefits of public health, therapeutic and vaccine interventions during a pandemic/epidemic.
  • Co-Project Investigators: Jane Heffernan, Jude Dzevela Kong, Iain Moyles, Hanna Jankowski (York University), Jacques Bélair (Université de Montréal), James Watmough (University of New Brunswick), Matthew Betti (Mount Allison University)
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Evolution of the virus: variants, transmission bottlenecks and fitness
Matthew Betti »Matthew Betti
James Watmough »James Watmough
Jane Heffernan »Jane Heffernan
Jude Kong »Jude Kong
Jacques Bélair »Jacques Bélair
Iain Moyles »Iain Moyles
Hanna Jankowski »Hanna Jankowski
Immunology »Immunology
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