Mechanistic principles can't explain the mind
The sould and mind are not made of the same kind of substance as external bodies are, and mechanism can't explain their workings.
So, although inanimate objects, plants, animals and the bodies of humans can be understood by applying physical (mechanistic) laws, the mind of man needs a completely different kind of explanation.

René Descartes (1637).

Notes: Descartes both supports and disputes mechanism. On the one hand he thinks the bodies are mechanistic but on the other hand he thinks that minds aren't mechanistic.
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