3. Safety
The war on marijuana, like alcohol prohibition before it, creates and fuels the criminal underclass, organized crime, and domestic and foreign drug cartels. It is basic Economics 101: where there is a demand, a supply will be created to meet it, period. Human demand for marijuana, like alcohol, has lasted thousands of years, and will never go away. Leading economists like Milton Friedman have long seen the drug war as an economically-bankrupt policy.
If marijuana were legalized and taxed, violent drug cartels would lose the principal source of their income. Marijuana ought to be treated like a more dangerous substance: alcohol, available at the corner liquor store, and taxed and regulated. How many Mexican drug cartels smuggle beer over the border? Ban it, and you would see many. Create a regulated legal market for it, and the drug cartels are not involved.