In preparing this review, we are hoping that it will encourage people to become actively engaged with the use of neuroleptics in the treatment of individuals experiencing psychotic symptoms. Overall, it represents a critical discourse concerning the use of these medications and their indications, as well as any problems associated with them. These perspectives are embedded in a scientific context to emphasize that this is not an ideological discussion, but rather an attempt to promote scientifically founded decisions on the behalf of clients. Consequently, a key portion of this contribution addresses the issue of “What to do?” Responding to patients’ needs means finding ways of utilizing these medications that offer the greatest benefits, with the fewest possible unwanted effects, for individuals experiencing psychoses. In addition, it deals with the ways in which neuroleptics can be most effectively and reasonably combined with other interventions. The aim of treatment is always to keep patients’ well being in mind.