Timing and severity of pandemics?

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Controlling Infectious Diseases
Diseases
Influenza
Outstanding questions in 2002
Timing and severity of pandemics?
What causes some (e.g. that of 1918) to be so lethal?
What factors most strongly influence when new pandemics will occur?
Implications for vaccination and antiviral drug strategies?
Inter-hemispheric transmission vs over-summer carry-over?
Reciprocal effects of intervention programmes?
Self-organization of strain structure & patterns of cross-reactivity?
What are the mechanisms of interaction between subtypes?
What makes the influenza so strongly seasonal?
Why do drifting subtypes persist and yet not diverge?
Graph of this discussion
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