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Self-organization of strain structure & patterns of cross-reactivity?

How do strain structure and patterns of cross-reactivity self-organize over evolutionary time (e.g. into quasi-species)?

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Outstanding questions in 2002
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Self-organization of strain structure & patterns of cross-reactivity?
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How does this organization feed back to affect dynamics?
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Implications for vaccination and antiviral drug strategies?
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Inter-hemispheric transmission vs over-summer carry-over?
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Reciprocal effects of intervention programmes?
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Timing and severity of pandemics?
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What are the mechanisms of interaction between subtypes?
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What makes the influenza so strongly seasonal?
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Why do drifting subtypes persist and yet not diverge?
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