Vaccination and antimicrobials, from the individual to the population
Vaccination and antimicrobials, from the individual to the population: Real-time modelling and data analysis to project therapeutic intervention.
- Vaccination and antimicrobials are a critical piece of the pharmaceutical arsenal in the fight against (R-) emerging infectious disease (EID). The COVID-19 pandemic has shown that deploying treatment and vaccination in the middle of a crisis poses specific complications, particularly when the efficacy and protection of different interventions against the pathogen’s evolutionary landscape are not fully understood. Rapid and accurate forecasting of drug and vaccine dosing needs is paramount to successful public health planning. Grasping the population-level consequences of individual-level properties of therapeutic tools is crucial. The project aims to develop within-host mathematical models of pathogen evolution and pharmaceutical interventions and link them to population-level public health intervention models. To support this work, we will incorporate new data analysis and visualization tools and population genetics.
- Co-Project Investigators: Morgan Craig (Université de Montréal), Stéphanie Portet, Julien Arino and Kang Ling Liao (University of Manitoba)