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Abstract

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Objectives The Centers for Disease Control and Prevention's HIV/AIDS Prevention research Synthesis Team conducted a systematic review of US-based HIV behavioral itnervention research literature from 2000-2004 to identify interventions demonstarting best evidence of efficacy for reducing HIV risk.
Methods Standard systematic review methods were used. Each eligible study was reviews on the basis of Prevention Research Sysnthesis Team efficacy criteria the focused on three domains: study design, implementation and analysis and strength of evidence.
Results Eighteen interventiosn met the criteria for best evidence. Four targeted drug users, six targeted adults at risk because of heterosexuals behaviors only, two targeted men who have sex with men and two targeted youths at hight risk. Eight interventions focused on women and thirteen had study samples with more than 50% minority participants. Significiant interventions effects included increased condom use and reductions in unproteced sexual intercourse, number of sexual partners, injection durg use or needle sharing, and newly acquired sexually transmitted infections.
Conclusion Most of the best-evidence interventions are directly applicable for populations in greatest need of effective prevention prorams; however, important gaps still exist.